Early and aggressive treatment for Crohn disease using biologics and immunomodulators.

Traditionally, medical providers have used the step-up approach to manage patients with Crohn disease, starting with 5-aminosalicylic acid derivatives, progressing to corticosteroids, and eventually to immunomodulators and biologics. However, a new top-down approach focuses on early and aggressive therapy with biologics and immunomodulators to reduce the rate of mucosal and intestinal damage. This article describes early and aggressive biologic and immunomodulator therapies and new therapeutic parameters compared with traditional step-up treatment for patients with Crohn disease. Copyright © 2024 American Academy of Physician Associates.

Citation

Erin Martin, Catherine K Sadowski. Early and aggressive treatment for Crohn disease using biologics and immunomodulators. JAAPA : official journal of the American Academy of Physician Assistants. 2024 May 01;37(5):1-5

Mesh Tags

Substances

PMID: 38662903

search → result