Transcript tinkering: RNA modifications in protozoan parasites.

Apicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling the study of the 'epitranscriptome' and how parasites evolved RNA modification-mediated mechanisms adapted to their unique lifestyles. Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Tiziano Vignolini, Justine E C Couble, Grégory R G Doré, Sebastian Baumgarten. Transcript tinkering: RNA modifications in protozoan parasites. Current opinion in microbiology. 2024 Jun;79:102477

Mesh Tags

Substances

PMID: 38663181

search → result