Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Digestive tract cancer is one of the most common types of cancers globally, with ~4.8 million new cases and 3.4 million cancer‑associated deaths in 2018, accounting for 26% of cancer incidence and 35% of cancer‑related deaths worldwide. S100 protein family is involved in regulating cancer cell proliferation, angiogenesis, epithelial‑mesenchymal transition (EMT), metastasis, metabolism and immune microenvironment homeostasis. The critical role of S100 protein family in digestive tract cancer involves complicated mechanisms, such as cancer stemness remodeling, anaerobic glycolysis regulation, tumor‑associated macrophage differentiation and EMT. The present study systematically reviewed published studies on the compositions, function and the underlying molecular mechanisms of the S100 family, as well as guidance for diagnosis, treatment and prognosis of digestive tract cancer. Systematic review of the roles and underlying molecular mechanisms of S100 protein family may provide new insight into exploring potential cancer biomarkers and the optimized therapeutic strategies for digestive tract cancer.

Citation

Mingshuai Li, Peng Cui, Wenqing Dai, Bo Cao, Haobin Zhao, Shuyu Jin, Donghua Xu, Youkui Shi, Shushan Yan. S100 protein family: Emerging role and mechanism in digestive tract cancer (Review). International journal of oncology. 2024 Jun;64(6)

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 38666531

View Full Text