Treg-tissue cell interactions in repair and regeneration.

Regulatory T (Treg) cells are classically known for their critical immunosuppressive functions that support peripheral tolerance. More recent work has demonstrated that Treg cells produce pro-repair mediators independent of their immunosuppressive function, a process that is critical to repair and regeneration in response to numerous tissue insults. These factors act on resident parenchymal and structural cells to initiate repair in a tissue-specific context. This review examines interactions between Treg cells and tissue-resident non-immune cells-in the context of tissue repair, fibrosis, and cancer-and discusses areas for future exploration. © 2024 Loffredo et al.

Citation

Lucas F Loffredo, Thomas M Savage, Olivia R Ringham, Nicholas Arpaia. Treg-tissue cell interactions in repair and regeneration. The Journal of experimental medicine. 2024 Jun 03;221(6)

Mesh Tags

PMID: 38668758

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