Emiliya V Nosova, Galina N Lipunova, Yulia V Permyakova, Valery N Charushin
European journal of medicinal chemistry 2024 May 05This review covers article and patent data obtained mostly within the period 2013-2023 on the synthesis and biological activity of quinazolines [c]-annelated by five- and six-membered heterocycles. Pyrazolo-, benzimidazo-, triazolo- and pyrimido- [c]quinazoline systems have shown multiple potential activities against numerous targets. We highlight that most research efforts are directed to design of anticancer and antibacterial agents of azolo[c]quinazoline nature. This review emphases both on the medicinal chemistry aspects of pyrrolo[c]-, azolo[c]- and azino[c]quinazolines and comprehensive synthetic strategies of quinazolines annelated at N(3)-C(4) bond in the perspective of drug development and discovery. Copyright © 2024 Elsevier Masson SAS. All rights reserved.
Emiliya V Nosova, Galina N Lipunova, Yulia V Permyakova, Valery N Charushin. Quinazolines annelated at the N(3)-C(4) bond: Synthesis and biological activity. European journal of medicinal chemistry. 2024 May 05;271:116411
PMID: 38669910
View Full Text