HPLC-Based Automated Synthesis and Purification of Carbohydrates.

Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides. © 2024 Wiley-VCH GmbH.

Citation

Gustavo A Kashiwagi, Laura Petrosilli, Samira Escopy, Luigi Lay, Keith J Stine, Cristina De Meo, Alexei V Demchenko. HPLC-Based Automated Synthesis and Purification of Carbohydrates. Chemistry (Weinheim an der Bergstrasse, Germany). 2024 Aug 01;30(43):e202401214

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PMID: 38684455

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