James G Krueger, Kilian Eyerich, Vijay K Kuchroo, Christopher T Ritchlin, Maria T Abreu, M Merle Elloso, Anne Fourie, Steven Fakharzadeh, Jonathan P Sherlock, Ya-Wen Yang, Daniel J Cua, Iain B McInnes
Frontiers in immunology 2024Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases. We propose studies to advance IL-23 biology and unravel differences in response to anti-IL-23 therapy. Experimental evidence generated from these investigations could establish a novel molecular ontology centered around IL-23-driven diseases, improve upon current approaches to treating IMIDs with IL-23 inhibition, and ultimately facilitate optimal identification of patients and, thereby, outcomes. Copyright © 2024 Krueger, Eyerich, Kuchroo, Ritchlin, Abreu, Elloso, Fourie, Fakharzadeh, Sherlock, Yang, Cua and McInnes.
James G Krueger, Kilian Eyerich, Vijay K Kuchroo, Christopher T Ritchlin, Maria T Abreu, M Merle Elloso, Anne Fourie, Steven Fakharzadeh, Jonathan P Sherlock, Ya-Wen Yang, Daniel J Cua, Iain B McInnes. IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy. Frontiers in immunology. 2024;15:1331217
PMID: 38686385
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