An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging.

An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.

Citation

Jaewon Kim, Jiyoung Yoo, Byungkook Kim, Kyung-Woo Lee, Sunghyun Kim, Sukwon Hong, Jong Seung Kim. An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging. Chemical communications (Cambridge, England). 2024 May 16;60(41):5443-5446

Mesh Tags

PMID: 38686636

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