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This study primarily aimed to assess the expression of MUC4 in patients with pancreatic ductal adenocarcinoma (PDAC) as compared with controls and assess its clinical relevance. Serum MUC4 levels and MUC4 gene expression in snap-frozen tissue were analyzed through surface plasmon resonance and quantitative polymerase chain reaction, respectively. Tumor tissues and control tissues were analyzed for MUC4 and other mucins through immunohistochemistry. MUC4 expression in tumor tissue was found to be significantly elevated in PDAC patients as compared with chronic pancreatitis tissues and normal pancreatic tissues. Periampullary carcinoma and cholangiocarcinoma tissue also showed increased expression of MUC4 and other mucins. Differential expression of MUC4 in pancreatic tumor tissues can help to differentiate PDAC from benign conditions. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Sumaira Rashid, Nidhi Singh, Safoora Rashid, Prasenjit Das, Surabhi Gupta, Shyam S Chauhan, Hem Chandra Sati, Nihar Ranjan Dash, Atul Sharma, Sharmistha Dey, Anoop Saraya. Clinical Significance of MUC4 and Associated Proteins in Pancreatic and Periampullary Cancers. Pancreas. 2024 Aug 01;53(7):e595-e602

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PMID: 38696350

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