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In recent decades, allergic diseases subsequent from an IgE-mediated response to specific allergens have become a progressively public chronic disease worldwide. They have shaped an important medical and socio-economic burden. A significant proportion of allergic disorders are branded via a form 2 immune response relating Th2 cells, type 2 natural lymphoid cells, mast cells and eosinophils. Interleukin-21 (IL-21) is a participant of the type-I cytokine family manufactured through numerous subsets of stimulated CD4+ T cells and uses controlling properties on a diversity of immune cells. Increasingly, experimental sign suggests a character for IL-21 in the pathogenesis of numerous allergic disorders. The purpose of this review is to discuss the biological properties of IL-21 and to summaries current developments in its role in the regulation of allergic disorders. Copyright © 2024 Elsevier B.V. All rights reserved.

Citation

Mohamed J Saadh, Mohammed A Alfattah, Ahmed H Ismail, Bashar Abdullah Saeed, Huda Hayder Abbas, Nabila F Elashmawy, Ghassan A Hashim, Khatib Sayeed Ismail, Mabrouk A Abo-Zaid, Hisham Ali Waggiallah. The role of Interleukin-21 (IL-21) in allergic disorders: Biological insights and regulatory mechanisms. International immunopharmacology. 2024 Jun 15;134:111825

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PMID: 38723368

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