Cognitive-Behavioral Therapy Enhancement Strategies.

David F Tolin, Kayla A Lord, Kelly A Knowles

The Psychiatric clinics of North America 2024 Jun

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We review the literature on various strategies to augment cognitive-behavioral therapy (CBT). Although traditional pharmacotherapy has only a small additive effect, research demonstrates that it is possible to select interventions that potentiate known mechanisms of CBT. D-cycloserine appears to potentiate activity at the N-methyl D-ethyl aspartate receptor and thereby facilitates fear extinction. Exercise may increase neural plasticity and thereby increase the efficacy of CBT for depression and anxiety. Noninvasive brain stimulation is thought to target the specific cortical regions needed for CBT response, but results have been mixed. Several other compounds appear promising but await controlled research before their efficacy as an augmentation strategy can be determined. Copyright © 2024 Elsevier Inc. All rights reserved.

Citation

David F Tolin, Kayla A Lord, Kelly A Knowles. Cognitive-Behavioral Therapy Enhancement Strategies. The Psychiatric clinics of North America. 2024 Jun;47(2):355-365