Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

25 years after the discovery of claudins as the central constituents of tight junctions, the "hunter-gatherer phase" of claudin research is coming to an end. Deficiency in individual claudins as a cause of rare hereditary diseases is well documented. However, knowledge about the involvement of renal claudins in common kidney diseases and strategies to utilize claudins or their regulators for intervention are still scarce. The present review summarizes novel approaches to address these questions. Publicly accessible omics data provide new insights not only into general claudin expression patterns along the nephron, but also into sex-specific differences in claudin expression and into claudin dysregulation in renal injury. Computational association studies identify claudin variants as risk factors for kidney disease such as nephrolithiasis or loss of filtration capacity. The establishment of innovative cell culture and organoid models contributes to a better understanding of junctional and extra-junctional functions of individual claudins. The current studies lay the foundation for the identification of upstream regulators of renal claudin expression and thus for the development of new concepts for the treatment of kidney disease. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Arnold Tsamo Tetou, Dorothee Günzel. The role of claudins in renal transepithelial transport and kidney disease. Current opinion in nephrology and hypertension. 2024 Sep 01;33(5):535-542

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 38726758

View Full Text