Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons.

Gowri Kalugotla, Vivien Marmerstein, Megan T Baldridge

Current opinion in immunology 2024 Apr

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Interferons (IFNs) are an integral component of the host innate immune response during viral infection. Recent advances in the study of type I and III IFNs suggest that though both types counteract viral infection, type III IFNs act predominantly at epithelial barrier sites, while type I IFNs drive systemic responses. The dynamics and specific roles of type I versus III IFNs have been studied in the context of infection by a variety of enteric pathogens, including reovirus, rotavirus, norovirus, astrovirus, and intestinal severe acute respiratory syndrome coronavirus 2, revealing shared patterns of regulatory influence. An important role for the gut microbiota, including the virome, in regulating homeostasis and priming of intestinal IFN responses has also recently emerged. Copyright © 2024 Elsevier Ltd. All rights reserved.

Citation

Gowri Kalugotla, Vivien Marmerstein, Megan T Baldridge. Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons. Current opinion in immunology. 2024 Apr;87:102425