Relative Bioavailability Assessment of Solid Forms by An Artificial Stomach and Duodenum Apparatus.

In this work, the ability of the artificial stomach and duodenum (ASD) model to predict bioavailability in rats was investigated using a poorly soluble model compound, BI-639667. A solution and four suspensions of different solid forms of BI-639667 were tested both in an ASD and rats. Rank order of the bioavailability estimated from an ASD apparatus is consistent with that of in vivo result in rats, i.e., solution > salicylic acid cocrystal > malate salt > maleate salt > monohydrate, which correlates with the ability of the different solid forms to maintain supersaturation with respect to the stable form in aqueous solution. The results support the use of an ASD for characterizing dissolution performance of solid forms to aid their selection for tablet formulation development. Copyright © 2024 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

Citation

Yiwang Guo, Alexander Byer-Alcorace, Cody Thomas, Stephanie Piekos, Laibin Luo, Michael Hawley, Changquan Calvin Sun. Relative Bioavailability Assessment of Solid Forms by An Artificial Stomach and Duodenum Apparatus. Journal of pharmaceutical sciences. 2024 Aug;113(8):2506-2512

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PMID: 38768754

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