Phosphatidylinositol 3,4-bisphosphate: Out of the shadows and into the spotlight.

Jayatee Ray, David G Sapp, Gregory D Fairn

Current opinion in cell biology 2024 Jun

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Phosphoinositide 3-kinases regulate many cellular functions, including migration, growth, proliferation, and cell survival. Early studies equated the inhibition of Class I PI3Ks with loss of; phosphatidylinositol 3,4,5-trisphosphate (PIP3), but over time, it was realised that these; treatments also depleted phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). In recent years, the; use of better tools and an improved understanding of its metabolism have allowed for the; identification of specific roles of PI(3,4)P2. This includes the production of PI(3,4)P2 and the; activation of its effector Akt2 in response to growth factor signalling. In contrast, a lysosomal pool of PI(3,4)P2 is a negative regulator of mTORC1 during growth factor deprivation. A growing body of literature also demonstrates that PI(3,4)P2 controls many dynamic plasmalemmal processes. The significance of PI(3,4)P2 in cell biology is increasingly evident. Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Citation

Jayatee Ray, David G Sapp, Gregory D Fairn. Phosphatidylinositol 3,4-bisphosphate: Out of the shadows and into the spotlight. Current opinion in cell biology. 2024 Jun;88:102372