Activated CD8+ T cells directly kill target cells. Therefore, the regulation of their function is central to avoiding immunopathology. Mechanisms that curb effector functions in CD4+ and CD8+ T cells are mostly shared, yet important differences occur. Here, we focus on the control of CD8+ T cell activity and discuss the importance of a poorly understood aspect of tolerance that directly impairs engagement of target cells: the downregulation of CD8. We contextualize this process and propose that it represents a key element during CD8+ T cell modulation. Copyright © 2024 Elsevier Ltd. All rights reserved.
Noé Rodríguez-Rodríguez, Florencia Rosetti, José C Crispín. CD8 is down(regulated) for tolerance. Trends in immunology. 2024 Jun;45(6):442-453
PMID: 38782625
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