Bone and Extracellular Signal-Related Kinase 5 (ERK5).

Lei Wen, Zirui Liu, Libo Zhou, Zhongcheng Liu, Qingda Li, Bin Geng, Yayi Xia

Biomolecules 2024 May 04

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Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5's significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5.

Citation

Lei Wen, Zirui Liu, Libo Zhou, Zhongcheng Liu, Qingda Li, Bin Geng, Yayi Xia. Bone and Extracellular Signal-Related Kinase 5 (ERK5). Biomolecules. 2024 May 04;14(5)