Subgenomic flavivirus RNA as key target for live-attenuated vaccine development.

Kristel Doets, Gorben P Pijlman

Journal of virology 2024 Jul 23

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Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.

Citation

Kristel Doets, Gorben P Pijlman. Subgenomic flavivirus RNA as key target for live-attenuated vaccine development. Journal of virology. 2024 Jul 23;98(7):e0010023