Nonlinear Elasticity of Blood Vessels and Vascular Grafts.

The transplantation of vascular grafts has emerged as a prevailing approach to address vascular disorders. However, the development of small-diameter vascular grafts is still in progress, as they serve in a more complicated mechanical environment than their counterparts with larger diameters. The biocompatibility and functional characteristics of small-diameter vascular grafts have been well developed; however, mismatch in mechanical properties between the vascular grafts and native arteries has not been accomplished, which might facilitate the long-term patency of small-diameter vascular grafts. From a point of view in mechanics, mimicking the nonlinear elastic mechanical behavior exhibited by natural blood vessels might be the state-of-the-art in designing vascular grafts. This review centers on elucidating the nonlinear elastic behavior of natural blood vessels and vascular grafts. The biological functionality and limitations associated with as-reported vascular grafts are meticulously reviewed and the future trajectory for fabricating biomimetic small-diameter grafts is discussed. This review might provide a different insight from the traditional design and fabrication of artificial vascular grafts.

Citation

Xiaofeng Wang, Kecheng Li, Yuan Yuan, Ning Zhang, Zifan Zou, Yun Wang, Shujie Yan, Xiaomeng Li, Peng Zhao, Qian Li. Nonlinear Elasticity of Blood Vessels and Vascular Grafts. ACS biomaterials science & engineering. 2024 Jun 10;10(6):3631-3654

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PMID: 38815169

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