Coma Blister After Trazodone Misuse: A Case Report.

Seanna Yang, Vivien Chen, Carole Bitar

The American Journal of dermatopathology 2024 Oct 01

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Coma blisters are epidermal and subepidermal bullous lesions that can arise throughout the body after a prolonged impairment of consciousness. Coma blister-like lesions have been well-documented in adults after barbiturate-induced intoxication. More recently, other drugs and substances have been associated with the development of these bullae, which has broadened the scope of medications that put patients at risk of developing coma blister-like lesions. We present a unique case of a noncomatose patient who developed coma blister-like lesions after trazodone misuse. This case illustrates the need to further investigate the mechanism behind drug-induced coma bullae-like lesions so that clinicians can better identify and discontinue drugs that precipitate such lesions. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Seanna Yang, Vivien Chen, Carole Bitar. Coma Blister After Trazodone Misuse: A Case Report. The American Journal of dermatopathology. 2024 Oct 01;46(10):e96-e97