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Amyloidosis is a heterogenous group of disorders, caused by the deposition of insoluble fibrils derived from misfolded proteins in the extracellular space of various organs. These proteins have an unstable structure that causes them to misfold, aggregate, and deposit as amyloid fibrils with the pathognomonic histologic property of green birefringence when viewed under cross-polarized light after staining with Congo red. Amyloid fibrils are insoluble and degradation-resistant; resistance to catabolism results in progressive tissue amyloid accumulation. The outcome of this process is organ disfunction independently from the type of deposited protein, however there can be organ that are specifically targeted from certain proteins. Copyright © 2024 Elsevier Inc. All rights reserved.

Citation

Marco Pozzan, Carla Indennidate, Guerino Giuseppe Varrà, Gianfranco Sinagra, Marco Merlo, Linda Pagura. Amyloidosis and Amyloidogenesis: One Name, Many Diseases. Heart failure clinics. 2024 Jul;20(3):249-260

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PMID: 38844296

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