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Prognostic significance of FAT10 expression in malignant tumors: a systematic review and meta-analysis.

Yi Zhang, Zheng Li, Xi Chen, Ying Huang, Bingwen Zou, Yong Xu

Future oncology (London, England) 2024


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    Aim: FAT10, a ubiquitin-like modifier protein, influences apoptosis, DNA damage response and tumor growth, with unclear effects on cancer prognosis.Methods: We reviewed FAT10 expression's impact on malignancy prognosis through a systematic review and meta-analysis, including studies up to September 2023 from PubMed, EMBASE and Web of Science.Results: From 18 studies involving 2513 patients, FAT10 overexpression significantly reduced overall and disease-free survival across various tumors, indicating correlations with advanced disease stage, poor differentiation, lymph node metastasis and larger tumor size.Conclusion: FAT10's overexpression suggests a negative prognostic value in cancer, meriting further investigation.PROSPERO Registration Number: CRD42023431287.

    Citation

    Yi Zhang, Zheng Li, Xi Chen, Ying Huang, Bingwen Zou, Yong Xu. Prognostic significance of FAT10 expression in malignant tumors: a systematic review and meta-analysis. Future oncology (London, England). 2024;20(21):1505-1514

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    PMID: 38864667

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