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A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al.1 elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of cytotoxic T lymphocytes. Copyright © 2024 Elsevier Inc. All rights reserved.

Citation

Jialin Zhang, Peter M K Westcott. Claudin 18 turns up the heat in cancer. Immunity. 2024 Jun 11;57(6):1187-1189

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PMID: 38865963

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