Molecular subtypes of ischemic heart disease based on circadian rhythm.

Coronary atherosclerotic heart disease (CAD) is among the most prevalent chronic diseases globally. Circadian rhythm disruption (CRD) is closely associated with the progression of various diseases. However, the precise role of CRD in the development of CAD remains to be elucidated. The Circadian rhythm disruption score (CRDscore) was employed to quantitatively assess the level of CRD in CAD samples. Our investigation revealed a significant association between high CRDscore and adverse prognosis in CAD patients, along with a substantial correlation with CAD progression. Remarkably distinct CRDscore distributions were also identified among various subtypes. In summary, we have pioneered the revelation of the relationship between CRD and CAD at the single-cell level and established reliable markers for the development, treatment, and prognosis of CAD. A deeper understanding of these mechanisms may offer new possibilities for incorporating "the therapy of coronary heart disease based circadian rhythm" into personalized medical treatment regimens. © 2024. The Author(s).

Citation

Zhaokai Zhou, Ge Zhang, Zhan Wang, Yudi Xu, Hongzhuo Qin, Haonan Zhang, Pengpeng Zhang, Zhengrui Li, Shuai Xu, Xin Tan, Yiyao Zeng, Fengyi Yu, Shanshan Zhu, Le Chang, Youyang Zheng, Xinwei Han. Molecular subtypes of ischemic heart disease based on circadian rhythm. Scientific reports. 2024 Jun 19;14(1):14155

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PMID: 38898215

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