Get your receptors in a knot with new Wnt signaling agonists.

Lucie Wolf, Stephane Angers

Cell chemical biology 2024 Jun 20

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Pharmacological modulation of the Wnt/β-catenin signaling pathway holds promises for both basic research and therapeutic applications. In this issue of Cell Chemical Biology, Kschonsak et al.1 engineered knotted peptides that promote Wnt signaling by targeting ZNRF3 and serve as pharmacological tools for studying Wnt biology and supporting organoid growth. Copyright © 2024 Elsevier Ltd. All rights reserved.