Prevention of cardiotoxicity in childhood cancer survivors: In physical exercise, we trust.

In recent years, the mean survival rate of children after a cancer diagnosis has significantly improved. At the same time, a growing interest in short and long-term cardiovascular (CV) complications of cancer therapy, as well as long-term CV risk in childhood cancer survivors (CCS) developed, along with proposals of protocols for the diagnosis, management, and prevention of cancer therapy-related CV toxicity (CTR-CVT) in this population. Many clinical and individual risk factors for CTR-CVT have been identified, and a non-negligible prevalence of traditional CV risk factors has been described in this population, potentially associated with a further worsening in both CTR-CVT and long-term CV risk. Physical exercise (PE) represents a promising, free-of-cost and free-of-complications, helpful therapy for primary and secondary prevention of CTR-CVT in CCS. The present narrative review aims to summarize the most critical evidence available about CTR-CVT in CCS, focusing on the role of PE in this clinical scenario. Copyright © 2024. Published by Elsevier Inc.

Citation

Valentina Bucciarelli, Francesco Bianco, Giandomenico Bisaccia, Kristian Galanti, Allegra Arata, Mirella Ricci, Benedetta Bucciarelli, Michele Marinelli, Giulia Renda, Alberto Farinetti, Anna Vittoria Mattioli, Sabina Gallina. Prevention of cardiotoxicity in childhood cancer survivors: In physical exercise, we trust. Current problems in cardiology. 2024 Sep;49(9):102722

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PMID: 38908726

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