Role of neuromuscular blocking agents in the development of polyneuropathy and myopathy in critically ill patients].

Acquired critical illness weakness (AWCIP) is the most frequent neuromuscular disease in intensive care medicine departments. Its importance is given by the prolongation of hospital stay and the delayed recovery it causes to patients after hospitalization. The main objective of this study was to investigate the association between neuromuscular blocking agents and the development of acquired weakness in critically ill patients. We conducted a prospective study of 103 critically ill patients who were periodically monitored with electromyography. The development of AWCIP was observed in 63 patients. The group of patients who developed AWCIP had a significantly higher utilization of neuromuscular blocking agents than the group who did not develop AWCIP [79.4% vs 50%, OR:3.85 (1.63-9.39), p <0.02]; likewise, this group of patients had a longer ICU stay [32 days vs 14 days, OR: 1.11 (1.06-1.17), p <0. 001] and a longer mechanical ventilation time [24 days vs 9 days, OR:1.2 (1.11-1.32), p <0.001]. Neuromuscular blocking agents are a factor associated with the occurrence of AWCIP. Copyright © 2024 Elsevier España, S.L.U. All rights reserved.

Citation

Fernando Armestar, Sara Vitoria Rubio, Isabel Ojanguren Sabán, Jaume Coll-Cantí, Hipólito Perez Molto. Role of neuromuscular blocking agents in the development of polyneuropathy and myopathy in critically ill patients]. Medicina clinica. 2024 Oct 18;163(7):323-326

Mesh Tags

Substances

PMID: 38960793

search → result