Effect of Hb conformational changes on oxygen transport physiology.

Red blood cells (RBCs) are the primary mediators of oxygen transport in the human body, and their function is mainly achieved through conformational changes of hemoglobin (Hb). Hb is a tetramer composed of four subunits, with HbA being the predominant Hb in healthy adults, existing in two forms: tense state (T state) and relaxed state (R state). Endogenous regulators of Hb conformation include 2,3-diphosphoglyceric acid, carbon dioxide, protons, and chloride ions, while exogenous regulators include inositol hexaphosphate, inositol tripyrophosphate, benzabate, urea derivative L35, and vanillin, each with different mechanisms of action. The application of Hb conformational regulators provides new insights into the study of hypoxia oxygen supply issues and the treatment of sickle cell disease.

Citation

Ziyue Yin, Doudou Li, Qianwen Guo, Rong Wang, Wenbin Li. Effect of Hb conformational changes on oxygen transport physiology. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2024 Mar 28;49(3):467-475

Mesh Tags

Substances

PMID: 38970521

search → result