The role of immunoglobulin transport receptor, neonatal Fc receptor in mucosal infection and immunity and therapeutic intervention.

Shaoju Qian, Danqiong Zhang, Zishan Yang, Ruixue Li, Xuehan Zhang, Feifei Gao, Lili Yu

International immunopharmacology 2024 Sep 10

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The neonatal Fc receptor (FcRn) can transport IgG and antigen-antibody complexes participating in mucosal immune responses that protect the host from most pathogens' invasion via the respiratory, digestive, and urogenital tracts. FcRn expression can be triggered upon stimulation with pathogenic invasion on mucosal surfaces, which may significantly modulate the innate immune response of the host. As an immunoglobulin transport receptor, FcRn is implicated in the pathophysiology of immune-related diseases such as infection and autoimmune disorders. In this review, we thoroughly summarize the recent advancement of FcRn in mucosal immunity and its therapeutic strategy. This includes insights into its regulation mechanisms of FcRn expression influenced by pathogens, its emerging role in mucosal immunity and its potential probability as a therapeutic target in infection and autoimmune diseases. Copyright © 2024 Elsevier B.V. All rights reserved.

Citation

Shaoju Qian, Danqiong Zhang, Zishan Yang, Ruixue Li, Xuehan Zhang, Feifei Gao, Lili Yu. The role of immunoglobulin transport receptor, neonatal Fc receptor in mucosal infection and immunity and therapeutic intervention. International immunopharmacology. 2024 Sep 10;138:112583