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Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis. However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by inflammation and loss of immunosuppression. Fragile Treg cells are formatively, phenotypically and functionally diverse in various diseases, further complicating the role of Treg cells in the immunotherapeutic response and offering novel targets for disease treatment by modulating specific Treg subsets. In this review, we summarize findings on fragile Treg cells to provide a framework for characterizing the formation and role of fragile Treg cells in different diseases, and we discuss how this information may guide the development of more specific Treg-targeted immunotherapies. Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Xiyu Song, Ruo Chen, Jiaxin Li, Yumeng Zhu, Jianhua Jiao, Hongjiao Liu, Zhinan Chen, Jiejie Geng. Fragile Treg cells: Traitors in immune homeostasis? Pharmacological research. 2024 Aug;206:107297

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PMID: 38977207

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