Clear Search sequence regions


  • DMM (2)
  • joint disease (1)
  • medial meniscus (1)
  • mice (4)
  • osteoclast (1)
  • pathogenesis (1)
  • phenotypes (1)
  • Y (9)
  • Sizes of these terms reflect their relevance to your search.

    Osteoarthritis is a highly prevalent progressive joint disease that still requires an optimal therapeutic approach. Intermittent fasting is an attractive dieting strategy for improving health. Here this study shows that intermittent fasting potently relieves medial meniscus (DMM)- or natural aging-induced osteoarthritic phenotypes. Osteocytes, the most abundant bone cells, secrete excess neuropeptide Y (NPY) during osteoarthritis, and this alteration can be altered by intermittent fasting. Both NPY and the NPY-abundant culture medium of osteocytes (OCY-CM) from osteoarthritic mice possess pro-inflammatory, pro-osteoclastic, and pro-neurite outgrowth effects, while OCY-CM from the intermittent fasting-treated osteoarthritic mice fails to induce significant stimulatory effects on inflammation, osteoclast formation, and neurite outgrowth. Depletion of osteocyte NPY significantly attenuates DMM-induced osteoarthritis and abolishes the benefits of intermittent fasting on osteoarthritis. This study suggests that osteocyte NPY is a key contributing factor in the pathogenesis of osteoarthritis and intermittent fasting represents a promising nonpharmacological antiosteoarthritis method by targeting osteocyte NPY. © 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.

    Citation

    Yu-Xuan Qian, Shan-Shan Rao, Yi-Juan Tan, Zun Wang, Hao Yin, Teng-Fei Wan, Ze-Hui He, Xin Wang, Chun-Gu Hong, Hai-Jin Zeng, Yi Luo, Yan-Xin Duan, Hao Zhu, Xin-Yue Hu, Ling Zou, Yan Zhang, Bing-Bing Liu, Zhen-Xing Wang, Wei Du, Chun-Yuan Chen, Hui Xie. Intermittent Fasting Targets Osteocyte Neuropeptide Y to Relieve Osteoarthritis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 Sep;11(34):e2400196

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 38978353

    View Full Text