The role of integrins in brain health and neurodegenerative diseases.

Yunhao Cui, Taisia Rolova, Susanna C Fagerholm

European journal of cell biology 2024 Sep

filter terms:

Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth of physiological processes, including nervous system development and function. Interestingly, integrins are also recognized therapeutic targets for inflammatory diseases, such as multiple sclerosis. Here, we discuss the role of integrins in brain development and function, as well as in neurodegenerative diseases affecting the brain (Alzheimer's disease, multiple sclerosis, stroke). Furthermore, we discuss therapeutic targeting of these adhesion receptors in inflammatory diseases of the brain. Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.

Citation

Yunhao Cui, Taisia Rolova, Susanna C Fagerholm. The role of integrins in brain health and neurodegenerative diseases. European journal of cell biology. 2024 Sep;103(3):151441