Steroid-induced psychosis: a spectrum of neuropsychiatric glucocorticoid side effects.

Glucocorticoid-induced neuropsychiatric side effects have been known since their initial usage and frequently manifest in clinical settings. Despite this, they remain unpredictable, variable and complex to manage, impacting patient outcomes and the healthcare system.We report a case of glucocorticoid-induced psychosis after the administration of dexamethasone post-neurosurgical intervention and its evolution with the initiation of chemotherapy. Although initially manic symptoms were prominent, with the beginning of chemotherapy psychotic symptoms dominated the clinical presentation, followed by depressive symptoms. Despite challenges in diagnosis and management, including adverse reactions to antipsychotic treatment, this case provides critical insights into the variable and dynamic nature of neuropsychiatric side effects induced by glucocorticoids. © BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.

Citation

Leonor Brito-Santana, Raquel Luís Medinas, António Neves, Joaquim Gago. Steroid-induced psychosis: a spectrum of neuropsychiatric glucocorticoid side effects. BMJ case reports. 2024 Jul 22;17(7)

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PMID: 39038870

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