Romina M Rodríguez, Marina Colom-Pellicer, Julia Hernández-Baixauli, Enrique Calvo, Manuel Suárez, Anna Arola-Arnal, Cristina Torres-Fuentes, Gerard Aragonès, Miquel Mulero
International journal of molecular sciences 2024 Jul 14This study investigated the influence of photoperiod (day length) on the efficacy of grape seed proanthocyanidin extract (GSPE) in mitigating metabolic disorders in obese rats fed a cafeteria diet. Rats were exposed to standard (L12), long (L18), or short (L6) photoperiods and treated with GSPE or vehicle. In the standard photoperiod, GSPE reduced body weight gain (50.5%), total cholesterol (37%), and triglycerides (34.8%), while increasing the expression of hepatic metabolic genes. In the long photoperiod, GSPE tended to decrease body weight gain, increased testosterone levels (68.3%), decreased liver weight (12.4%), and decreased reverse serum amino acids. In the short photoperiod, GSPE reduced glycemia (~10%) and lowered triglyceride levels (38.5%), with effects modified by diet. The standard photoperiod showed the greatest efficacy against metabolic syndrome-associated diseases. The study showed how day length affects GSPE's benefits and underscores considering biological rhythms in metabolic disease therapies.
Romina M Rodríguez, Marina Colom-Pellicer, Julia Hernández-Baixauli, Enrique Calvo, Manuel Suárez, Anna Arola-Arnal, Cristina Torres-Fuentes, Gerard Aragonès, Miquel Mulero. Grape Seed Proanthocyanidin Extract Attenuates Cafeteria-Diet-Induced Liver Metabolic Disturbances in Rats: Influence of Photoperiod. International journal of molecular sciences. 2024 Jul 14;25(14)
PMID: 39062955
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