Zhangling Chen, Cheng Wei, Sander Lamballais, Kang Wang, Yuchan Mou, Yichao Xiao, Fei Luo, Wichor M Bramer, Trudy Voortman, Shenghua Zhou
Nutrition journal 2024 Jul 31Artificially sweetened beverages (ASB) are consumed globally, but their impact on overall health remains uncertain. We summarized published associations between ASB intake with all-cause and cause-specific mortality. We searched Medline, Embase, Web of Science, and Cochrane CENTRAL databases until August 2023. Random effect meta-analysis was conducted to calculate pooled risk ratios (RRs) and 95% confidence intervals (95%CIs) for highest versus lowest categories of ASB consumption in relation to all-cause and cause-specific mortality. Linear and non-linear dose-response analyses were also performed. Our systematic review and meta-analysis included 11 prospective cohort studies. During a median/mean follow-up period of 7.0 to 28.9 years, 235,609 deaths occurred among 2,196,503 participants. Intake of ASB was associated with higher risk of all-cause and CVD mortality with pooled RRs (95%CIs) of highest vs. lowest intake categories of 1.13 (1.06, 1.21) (I2 = 66.3%) for all-cause mortality and 1.26 (1.10, 1.44) (I2 = 52.0%) for CVD mortality. Dose-response analysis revealed a non-linear association of ASB with all-cause mortality (pnon-linearity = 0.01), but a linear positive association with CVD mortality (pnon-linearity = 0.54). No significant association was observed for ASB intake and cancer mortality. Moreover, a secondary meta-analysis demonstrated that replacing 1 serving/day of sugary sweetened beverages (SSB) with ASB was associated with 4-6% lower risk of all-cause and CVD mortality. Per NutriGrade, the evidence quality for associations between ASB intake with all-cause and CVD mortality was moderate. Higher intake of ASB was associated with higher risk of all-cause and CVD mortality, albeit a lower risk than for SSB. PROSPERO registration no. CRD42022365701. © 2024. The Author(s).
Zhangling Chen, Cheng Wei, Sander Lamballais, Kang Wang, Yuchan Mou, Yichao Xiao, Fei Luo, Wichor M Bramer, Trudy Voortman, Shenghua Zhou. Artificially sweetened beverage consumption and all-cause and cause-specific mortality: an updated systematic review and dose-response meta-analysis of prospective cohort studies. Nutrition journal. 2024 Jul 31;23(1):86
PMID: 39085903
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