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Dissociating the metabolic and tumor-suppressive activity of p53.
Trends in endocrinology and metabolism: TEM 2025 JanSizes of these terms reflect their relevance to your search.
The tumor suppressor p53 regulates metabolic homeostasis. Recently, Tsaousidou et al. reported that selective activation of p53 via downregulation of Tudor interacting repair regulator (TIRR) confers protection against cancer despite obesity and insulin resistance, providing new insights into the role of p53 at the intersection of oncogenesis and systemic metabolism. Copyright © 2024 Elsevier Ltd. All rights reserved.
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Yoshitaka Sakurai, Naoto Kubota, Takashi Kadowaki. Dissociating the metabolic and tumor-suppressive activity of p53. Trends in endocrinology and metabolism: TEM. 2025 Jan;36(1):4-6
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PMID: 39095229
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