IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing eosinophil activation.

Atopic dermatitis (AD) presents significant therapeutic challenges due to its poorly understood etiology. Eosinophilia, a hallmark of allergic inflammation, is implicated in AD pathogenesis. Interleukin-10 (IL-10)-producing regulatory B (Breg) cells exhibit potent anti-inflammatory effects. However, their role in controlling AD-related eosinophilia is not well understood. To investigate the impact of eosinophils on AD, we employed IL-5Rα-deficient (Il5ra-/-) mice, which lack functional eosinophils. Induction of AD in these mice resulted in attenuated disease symptoms, underscoring the critical role of eosinophils in AD development. Additionally, the adoptive transfer of purified Breg cells into mice with AD significantly alleviated disease severity. Mechanistic studies revealed that IL-10 produced by Breg cells directly inhibits eosinophil activation and infiltration into the skin. In vitro experiments further confirmed that Breg cells inhibited eosinophil peroxidase secretion in an IL-10-dependent manner. Our collective findings demonstrate that IL-10 from Breg cells alleviates AD by suppressing eosinophil activation and tissue infiltration. This study elucidates a novel regulatory mechanism of Breg cells, providing a foundation for future Breg-mediated therapeutic strategies for AD. © 2024. The Author(s).

Citation

Dajeong Lee, Min Geun Jo, Keun Young Min, Min Yeong Choi, Young Mi Kim, Hyuk Soon Kim, Wahn Soo Choi. IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing eosinophil activation. Scientific reports. 2024 Aug 06;14(1):18164

Mesh Tags

Substances

PMID: 39107352

search → result