Dissecting Out a Rare Mutation, STAT: Features of STAT3-Mutant Myeloid Neoplasms.

The transcription factor STAT3 drives the expression of genes promoting cellular proliferation, survival, and pluripotency. The description of STAT3 mutations and their clinical correlates in myeloid neoplasms, such as acute myeloid leukemia and myelodysplastic syndromes, raises new insights into both the pathogenesis and the targeted therapy of these diseases. See related article by Ye et al., p. 4681. ©2024 American Association for Cancer Research.

Citation

Michael J Hochman, David A Frank. Dissecting Out a Rare Mutation, STAT: Features of STAT3-Mutant Myeloid Neoplasms. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Oct 15;30(20):4554-4556

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PMID: 39110422

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