Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Glomerular hyperfiltration(GHF), as an early manifestation of prediabetes and diabetic kidney disease, occurs mainly by the mechanism of glomerular-tubular feedback and hemodynamic alterations, and the risk of hyperfiltration can be elevated in younger patients, shorter duration of the disease, poor glycemic control, and high-protein, low-salt diet. Currently, there is no recognized standard for the definition of GHF, GHF lacks typical clinical manifestations, imaging diagnostic criteria are unclear, and GHF-related laboratory markers need to be further studied. Hyperfiltration, if not diagnosed and intervened in time, can accelerate the damage of nephron and the rate of nephropathy progression, and increase the risk of complications and death. Sodium-glucose cotransporter 2 inhibitor(SGLT2i), glucagon-like peptide-1 receptor agonist(GLP-1RA)and so on can effectively reverse the hyperfiltration state. Clinical attention should be paid to the diagnosis of diabetic hyperfiltration and the prevention of its poor prognosis.

Citation

R X Ma, X J Wang, D Q Peng. Advances in the diagnosis and poor prognosis of diabetic hyperfiltration]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2024 Aug 06;58(8):125612621256-1262

Expand section icon Mesh Tags


PMID: 39142898

View Full Text