Pediatric reference values of NT-proBNP and Galectin-3 based on a French cohort.

In pediatric cardiology, the fact that some new biomarkers have assay-specific normal values has to be considered for correct clinical decisions. The current study aimed to provide age-adjusted normative values for NT-proBNP and Galectin-3 using the Abbott immunoassay system from a prospective French pediatric cohort sera collection and to validate our data for NT-proBNP on a second retrospective cohort. We analyzed 283 consecutive samples for NT-proBNP and 140 samples for Galectin-3 collected from apparently healthy children (0-18 years) with outpatient treatment at our institution (Hôpital Necker-Enfants malades, Paris, France) during 24 months. For NT-proBNP and Galectin-3, we establish four age partitions, respectively two (<2 years / >2 years) and establish upper reference values and their 90 % CI for each biomarker (Galectin-3 (ng/mL): 56 [44-70] / 26 [23-29]). We evaluated the diagnostic performance of our upper reference values of NT-proBNP on a retrospective cohort (n = 428) with positive predictive value of 0.92. Using Abbott immunoassay system, we report age-specific reference values for NT-proBNP and for the first time for Galectin-3 in a healthy French pediatric cohort. These data call for larger cohort studies to define more robustly percentiles and diagnostic performance for NT-proBNP. Copyright © 2024 Elsevier B.V. All rights reserved.

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Victor Gravrand, Corentin S Lefebvre, Fatma Hamza, Thibaud Della-Negra, Vincent Coyaud, Axelle Vasseur, Carole Hennequin, Valérie Nivet-Antoine, Damien Schaffner. Pediatric reference values of NT-proBNP and Galectin-3 based on a French cohort. Clinica chimica acta; international journal of clinical chemistry. 2025 Jan 01;564:119925

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PMID: 39151672

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