Ferroptosis: a potential target for acute lung injury.

Acute lung injury (ALI) is caused by a variety of intrapulmonary and extrapulmonary factors and is associated with high morbidity and mortality. Oxidative stress is an important part of the pathological mechanism of ALI. Ferroptosis is a mode of programmed cell death distinguished from others and characterized by iron-dependent lipid peroxidation. This article reviews the metabolic regulation of ferroptosis, its role in the pathogenesis of ALI, and the use of ferroptosis as a therapeutic target regarding the pharmacological treatment of ALI. © 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Citation

Yuqi Wen, Yang Liu, Weihong Liu, Wenli Liu, Jinyan Dong, Qingkuo Liu, Zhen Yu, Hongsheng Ren, Hao Hao. Ferroptosis: a potential target for acute lung injury. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2024 Oct;73(10):1615-1629

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PMID: 39152299

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