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Immunomodulatory therapies are beneficial strategies for the improvement of immune system function. Today, due to the increasing prevalence of immune disorders, cancer, and new viral diseases, there is a greater need to introduce immunomodulatory compounds with more efficiency and fewer side effects. Microbial derivatives are fertile and attractive grounds for discovering lots of novel compounds with various medical properties. The discovery of many natural compounds derived from bacterial sources, such as secondary metabolites with promising immunomodulating activities, represents the importance of this topic in drug discovery and emphasizes the necessity for a coherent source of study in this area. Considering this need, in this review, we aim to focus on the current information about the immunomodulatory effects of bacterial secondary metabolites and natural immunomodulators derived from microorganisms. Copyright © 2024 Elsevier B.V. All rights reserved.

Citation

Fariba Mahmoudi, Mohammad Hadi Tajik Jalayeri, Azadeh Montaseri, Leila MohamedKhosroshahi, Behzad Baradaran. Microbial natural compounds and secondary metabolites as Immunomodulators: A review. International journal of biological macromolecules. 2024 Oct;278(Pt 3):134778

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PMID: 39153680

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