Inhibition of Norovirus GII.4 binding to HBGAs by Sargassum fusiforme polysaccharide.

Yiqiang Sun, Meina Liang, Mingjiang Wu, Laijin Su

Bioscience reports 2024 Sep 25

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Norovirus (NoV) is the main pathogen that causes acute gastroenteritis and brings a heavy socio-economic burden worldwide. In this study, five polysaccharide fractions, labeled pSFP-1-5, were isolated and purified from Sargassum fusiforme (S. fusiforme). In vitro experiments demonstrated that pSFP-5 significantly prevented the binding of type A, B and H histo-blood group antigens (HBGAs) to NoV GII.4 virus-like particles (NoV GII.4 VLPs). In addition, in vivo experiments revealed that pSFP-5 was effective in reducing the accumulation of NoV in oysters, indicating that pSFP-5 could reduce the risk of NoV infection from oyster consumption. The results of transmission electron microscopy showed that the appearance of NoV GII.4 VLPs changed after pSFP-5 treatment, indicating that pSFP-5 may achieve antiviral ability by altering the morphological structure of the viral particles so that they could not bind to HBGAs. The results of the present study indicate that pSFP-5 may be an effective anti-NoV substance and can be used as a potential anti-NoV drug component. © 2024 The Author(s).

Citation

Yiqiang Sun, Meina Liang, Mingjiang Wu, Laijin Su. Inhibition of Norovirus GII.4 binding to HBGAs by Sargassum fusiforme polysaccharide. Bioscience reports. 2024 Sep 25;44(9)