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Pantoprazole is an extensively used proton pump inhibitor (PPI) for acid peptic disease. PPI rarely cause hypomagnesemia. Hypomagnesemia is commonly associated with hypokalemia and hypocalcemia. Severe hypomagnesemia and hypocalcemia can cause seizures. Here, we report a patient on long-term pantoprazole who presented with generalized tonic-clonic seizures and had severe hypomagnesemia, hypocalcemia, hypokalemia, and secondary hyperparathyroidism. When patients on long-term PPI present with seizures, hypomagnesemia/hypocalcemia has to be excluded. © Journal of the Association of Physicians of India 2024.

Citation

Somarajan Anandan, Sajeesh S Rajendran, Sourav Asha Somarajan, Archana Udayan. A Very Rare Side Effect of a Very Commonly Used Drug: Pantoprazole-induced Seizure. The Journal of the Association of Physicians of India. 2024 Aug;72(8):89

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PMID: 39163076

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