O-GlcNAcylation in tumorigenesis and its implications for cancer therapy.

O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic and reversible posttranslational modification that targets serine and threonine residues in a variety of proteins. Uridine diphospho-N-acetylglucosamine, which is synthesized from glucose via the hexosamine biosynthesis pathway, is the major donor of this modification. O-GlcNAc transferase is the sole enzyme that transfers GlcNAc onto protein substrates, while O-GlcNAcase is responsible for removing this modification. O-GlcNAcylation plays an important role in tumorigenesis and progression through the modification of specific protein substrates. In this review, we discuss the tumor-related biological functions of O-GlcNAcylation and summarize the recent progress in the development of pharmaceutical options to manipulate the O-GlcNAcylation of specific proteins as potential anticancer therapies. Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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Dize Zhang, Yihang Qi, Hiroyuki Inuzuka, Jing Liu, Wenyi Wei. O-GlcNAcylation in tumorigenesis and its implications for cancer therapy. The Journal of biological chemistry. 2024 Sep;300(9):107709

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PMID: 39178944

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