James Stewart New, Rodney Glenn King, Jeremy B Foote, John F Kearney
Current opinion in immunology 2024 AugMicrobiota-derived antigens play a critical role in the development of both the mucosal and systemic B cell repertoires; however, how glycan epitopes promote B cell repertoire selection is only recently being understood. The production of glycan-derived antigens by individual microbes within a host can be dynamic and influenced by interactions within other members of microbial communities, the composition of diet, and host-derived contents, including those of the mucosal immune system. The size and complexity of the emerging neonatal B cell repertoire are paralleled by the acquisition of a diverse microbiota from maternal and environmental sources, which is now appreciated to exert long-lasting influences on the nascent B cell repertoire. Copyright © 2024 Elsevier Ltd. All rights reserved.
James Stewart New, Rodney Glenn King, Jeremy B Foote, John F Kearney. Microbiota and B-1 B cell repertoire development in mice. Current opinion in immunology. 2024 Aug;89:102452
PMID: 39180941
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