Unweaving type I interferons in age-related neuroinflammation.

David P J Hunt, Markus J Hofer

Trends in neurosciences 2024 Oct

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Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation. Copyright © 2024 Elsevier Ltd. All rights reserved.