Chrysin downregulates the expression of ADAMTS-4 in foam cells.

Chrysin, a polyphenolic compound, possesses antioxidant and anti-inflammatory properties. In this study, we investigated the effect of chrysin on the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), a protease enzyme involved in degrading extracellular matrix associated with atherosclerosis. We have studied the cell viability by MTT assay and foam cell formation by oil red O staining. The mRNA and protein expression of ADAMTS-4 was studied using quantitative polymerase chain reaction (qPCR) and Western blotting, respectively. Our study showed that chrysin significantly downregulates the expression of ADAMTS-4 in foam cells. Chrysin's ability to downregulate the expression of ADAMTS-4, a protease involved in degrading the extracellular matrix, bestows upon it a new therapeutic potential for managing atherosclerosis. © 2024. The Author(s), under exclusive licence to Springer Nature B.V.

Citation

S S Aswani, Sreelekshmi G Jayan, Mithra S Mohan, N S Aparna, P T Boban, K Saja. Chrysin downregulates the expression of ADAMTS-4 in foam cells. Molecular biology reports. 2024 Sep 09;51(1):968

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PMID: 39249599

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