Unique Pharmacological Properties and Safety Profiles of Loop Diuretics.

Loop diuretics are regarded as essential for the treatment of edematous conditions in heart failure, cirrhosis, and renal disease. The principal mechanism of action involves inhibiting the reabsorption of ions (Na+, 2Cl-, and K+) from the ascending loop of Henle. The pharmacokinetic (PK) and pharmacodynamic (PD) features of the commonly used diuretics (torsemide, furosemide, and bumetanide) influence the selection of diuretics in various disease states and dosing regimens. However, torsemide demonstrates superior PK and PD qualities, making it the preferred choice. Genetic polymorphisms must be explored to better understand the diversity of PK and PD parameters of loop diuretics between individuals. © Journal of the Association of Physicians of India 2024.

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Mohan Lal, Prasant Kumar Sahoo, Mangesh Tiwaskar, Niranjan Nisty, Sharukh Golwala, Suvro Banerjee, Rajeev Krishna, Ashwani Mehta, Ashok Kumar, Naveen Garg, Gopinath Arumugam, Idris Ahmed Khan, Nitin Zalte, Senthilnathan Mohanasundaram. Unique Pharmacological Properties and Safety Profiles of Loop Diuretics. The Journal of the Association of Physicians of India. 2024 Sep;72(9S):16-18

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PMID: 39291567

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