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    This is the first report of NUP98::LEDGF positive malignant hematological tumor expressing T cell and myeloid lineage antigens. Patients carrying this fusion gene have a high relapse rate and a poor prognosis, allo-HSCT may be an option to cure this disease. This patient underwent allo-HSCT, a relapse occurred three months post-transplantation. Subsequent screening at our hospital confirmed the presence of the NUP98::LEDGF fusion gene, salvage therapy was administered, followed by a successful second allo-HSCT. Furthermore, we included eight previously reported cases from the literature for analysis and discuss. Copyright © 2024 Xue, Chen, Wang, Zhang, Chen, Sun and Cao.

    Citation

    Song Xue, Jia-Qi Chen, Tong Wang, Li-Na Zhang, Man Chen, Hui-Peng Sun, Xing-Yu Cao. Case report: NUP98::LEDGF fusion gene drives malignant hematological tumor with mixed immunological phenotype. Frontiers in oncology. 2024;14:1396655


    PMID: 39301554

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